Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.

PloS one - 1 Jan 2012

Xiao Yu, Karnati Srikanth, Qian Guofeng, Nenicu Anca, Fan Wei, Tchatalbachev Svetlin, Höland Anita, Hossain Hamid, Guillou Florian, Lüers Georg H, Baumgart-Vogt Eveline

Abstract excerpt

Cre-mediated excision of loxP sites is widely used in mice to manipulate gene function in a tissue-specific manner. To analyze phenotypic alterations related to Cre-expression, we have used AMH-Cre-transgenic mice as a model system. Different Cre expression levels were obtained by investigation of C57BL/6J wild type as well as heterozygous and homozygous AMH-Cre-mice. Our results indicate that Cre-expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Mullerian Hormone
Share to Antioxidants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Walking

Share to Integrases

Share to Peroxisomes

Share to Sertoli Cells

Share to Sirtuins

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 22829911
DOI: 10.1371/journal.pone.0041097
PMCID: PMC3400606

Genes

AMH
ABCD1
ABCD3
FOXO3
HMOX1
PEX13
PEX14
PEX5
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.PMID 22829911Read ↗

High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restrictionSemantic proximity Read ↗

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse ModelSemantic proximity Read ↗

Maternal corticosterone in the mouse alters oxidative stress markers, antioxidant function and mitochondrial content in placentas of female fetusesSemantic proximity Read ↗

Epigenetic silencing of SOD2 exacerbates mitochondrial oxidative stress and promotes pulmonary fibrosisSemantic proximity Read ↗

Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice.Semantic proximity Read ↗

Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null MiceSemantic proximity Read ↗

A Maternal High-Fat Diet Represses the Expression of Antioxidant Defense Genes and Induces the Cellular Senescence Pathway in the Liver of Male Offspring RatsSemantic proximity Read ↗

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in miceSemantic proximity Read ↗

Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathwaySemantic proximity Read ↗

The Cre/loxP system--a versatile tool to study glucocorticoid signalling in mice.Semantic proximity Read ↗

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing lossSemantic proximity Read ↗

Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.