Article
Interaction between sleep and metabolism in Drosophila with altered octopamine signaling.
The Journal of biological chemistry - 21 Sept 2012
Erion Renske, DiAngelo Justin R, Crocker Amanda, Sehgal Amita
Abstract excerpt
Sleep length and metabolic dysfunction are correlated, but the causal relationship between these processes is unclear. Octopamine promotes wakefulness in the fly by acting through the insulin-producing cells (IPCs) in the fly brain. To determine if insulin signaling mediates the effects of octopamine on sleep:wake behavior, we assayed flies in which insulin signaling activity was genetically altered. We found...
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