Article
CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.
The Journal of allergy and clinical immunology - 1 Mar 2012
van Montfrans Joris M, Hoepelman Andy I M, Otto Sigrid, van Gijn Marielle, van de Corput Lisette, de Weger Roel A, Monaco-Shawver Linda, Banerjee Pinaki P, Sanders Elisabeth A M, Jol-van der Zijde Cornelia M, Betts Michael R, Orange Jordan S, Bloem Andries C, Tesselaar Kiki
Abstract excerpt
BACKGROUND: CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural killer (NK) cell, B-cell, and plasma cell function, survival, and differentiation. On the basis of its function and expression pattern, we considered CD27 a candidate gene in patients with hypogammaglobulinemia. OBJECTIVE: We sought to describe the clinical and immunologic phenotypes of patients with genetic CD27 deficiency....
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