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Article

Monomeric 14-3-3ζ has a chaperone-like activity and is stabilized by phosphorylated HspB6.

Biochemistry - 7 Aug 2012

Sluchanko Nikolai N, Artemova Natalya V, Sudnitsyna Maria V, Safenkova Irina V, Antson Alfred A, Levitsky Dmitrii I, Gusev Nikolai B

Abstract excerpt

Members of the 14-3-3 eukaryotic protein family predominantly function as dimers. The dimeric form can be converted into monomers upon phosphorylation of Ser(58) located at the subunit interface. Monomers are less stable than dimers and have been considered to be either less active or even inactive during binding and regulation of phosphorylated client proteins. However, like dimers, monomers contain the...

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Source

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Identifiers

PMID: 22794279
DOI: 10.1021/bi300674e
PMCID: PMC3413243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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