Article
A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer.
PloS one - 1 Jan 2012
Luo Junhua, Cai Qingqing, Wang Wei, Huang Hui, Zeng Hong, He Wang, Deng Weixi, Yu Hao, Chan Eddie, Ng Chi-fai, Huang Jian, Lin Tianxin
Abstract excerpt
PURPOSE: To investigate the biological function of HOXB5 in human bladder cancer and explore whether the HOXB5 3'-UTR SNP (1010A/G), which is located within the microRNA-7 binding site, was correlated with clinical features of bladder cancer. METHODS: Expression of HOXB5 in 35 human bladder cancer tissues and 8 cell lines were examined using real-time PCR and immunohistochemistry. Next, we explored the biological...
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