Article
Association of COX-2 rs20417 with aspirin resistance.
Journal of thrombosis and thrombolysis - 1 Jan 2013
Sharma Vandana, Kaul Subhash, Al-Hazzani Amal, Alshatwi Ali A, Jyothy A, Munshi Anjana
Abstract excerpt
Aspirin is the most commonly used antiplatelet drug for treatment of a serious vascular event, most notably stroke and myocardial infarction. However, despite the demonstrated benefit of aspirin, significant fraction of aspirin-treated patients may be resistant to the antiplatelet effects of the drug. The possible mechanisms of aspirin resistance (AR) are multifactorial. A genetic basis for AR has been suggested...
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