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Article

Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature.

Journal of clinical microbiology - 1 Sept 2012

Scheutz Flemming, Teel Louise D, Beutin Lothar, Piérard Denis, Buvens Glenn, Karch Helge, Mellmann Alexander, Caprioli Alfredo, Tozzoli Rosangela, Morabito Stefano, Strockbine Nancy A, Melton-Celsa Angela R, Sanchez Maria, Persson Søren, O'Brien Alison D

Abstract excerpt

When Shiga toxin-producing Escherichia coli (STEC) strains emerged as agents of human disease, two types of toxin were identified: Shiga toxin type 1 (Stx1) (almost identical to Shiga toxin produced by Shigella dysenteriae type 1) and the immunologically distinct type 2 (Stx2). Subsequently, numerous STEC strains have been characterized that express toxins with variations in amino acid sequence, some of which...

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Identifiers

PMID: 22760050
DOI: 10.1128/JCM.00860-12
PMCID: PMC3421821

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