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Article

Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2012

Cui Yunfeng, Brosnan Jacqueline A, Blackford Amanda L, Sur Surojit, Hruban Ralph H, Kinzler Kenneth W, Vogelstein Bert, Maitra Anirban, Diaz Luis A, Iacobuzio-Donahue Christine A, Eshleman James R

Abstract excerpt

PURPOSE: Pancreatic cancer is the fourth cause of death from cancer in the western world. Majority of patients present with advanced unresectable disease responding poorly to most chemotherapeutic agents. Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs....

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Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

Share to Inhibitory Concentration 50

Share to Pancreatic Neoplasms

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Source

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Identifiers

PMID: 22753594
DOI: 10.1158/1078-0432.CCR-12-0827
PMCID: PMC3513499

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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