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Article

Cell Death via DR5, but not DR4, Is Regulated by p53 in Myeloma Cells

27 Jun 2012

Abstract excerpt

Myeloma cells are sensitive to TRAIL through the two death receptors DR4 and DR5. Because p53 directly modulates expression of death receptors, we investigated here whether p53 can modulate myeloma sensitivity to TRAIL. We found that p53 affects the sensitivity of myeloma cells to the DR5 agonistic human antibody lexatumumab but not the DR4 antibody mapatumumab. TP53 wild-type myeloma cells overexpressed DR5 in...

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PMID: 22738917
DOI: 10.1158/0008-5472.can-12-0487

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