Article
Elevated local TGF-β1 level predisposes a closed bone fracture to tuberculosis infection.
Medical hypotheses - 1 Sept 2012
Li Hao, Liang Cheng-zhen, Tao Yi-qing, Shen Cheng-chun, Chen Qi-xin
Abstract excerpt
Tuberculosis (TB) occurring after a closed bone fracture in the patient with no history of TB and no evidence of TB infection at the time of initial fracture is a rare entity. Transforming growth factor-beta 1 (TGF-β1) is a ubiquitous growth factor that is implicated in the regulation of the proliferation, differentiation, migration, and survival of many different cell types. Recent studies have demonstrated that...
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