Article
Expression, purification, and characterization of engineered antibody CH2 and VH domains.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Gong Rui, Chen Weizao, Dimitrov Dimiter S
Abstract excerpt
Most of the FDA-approved therapeutic monoclonal antibodies are full-size IgG molecules with a molecular weight of about 150 kDa. A major problem for such large molecules is their poor penetration into tissues (e.g., solid tumors) and poor or absent binding to regions on the surface of some molecu...
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