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Article

Mutagenesis of the residues forming an ion binding pocket of the NtpK subunit of Enterococcus hirae V-ATPase.

Journal of bacteriology - 1 Sept 2012

Kawano-Kawada Miyuki, Iwaki Tomoko, Hosaka Toshiaki, Murata Takeshi, Yamato Ichiro, Homma Michio, Kakinuma Yoshimi

Abstract excerpt

The crystal structures of the Na(+)- and Li(+)-bound NtpK rings of Enterococcus hirae V-ATPase have been obtained. The coupling ion (Na(+) or Li(+)) was surrounded by five oxygen atoms contributed by residues T64, Q65, Q110, E139, and L61, and the hydrogen bonds of the side chains of Q110, Y68, and T64 stabilized the position of the E139 γ carboxylate essential for ion occlusion (PDB accession numbers 2BL2 and...

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Identifiers

PMID: 22730119
DOI: 10.1128/JB.00714-12
PMCID: PMC3415527

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Source receipt: pubmed, retrieved 7 Sept 2026.

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