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Article

Beta zero-thalassemia in a Thai family is caused by a 3.4 kb deletion including the entire beta-globin gene.

Hemoglobin - 1 Jan 1990

Sanguansermsri T, Pape M, Laig M, Hundrieser J, Flatz G

Abstract excerpt

DNA analysis of a Northern Thai family with a child affected with beta-thalassemia major revealed a novel deletion of 3.4 kb removing the entire beta-globin gene in the proposita and her mother. Detailed mapping of the deletion located the 5' breakpoint in the region between nucleotides -810 and -128 of the beta-globin locus, and the 3' breakpoint between the Ava II and Xmn I sites located downstream of the...

Topics

Base Composition
Base Sequence
Child
Chromosome Deletion
DNA
Female
Globins
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thailand

Thalassemia

Source

Identifiers

PMID: 2272839
DOI: 10.3109/03630269009046957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2272839-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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