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Article

Satellite Cells Senescence in Limb Muscle of Severe Patients with COPD

13 Jun 2012

Abstract excerpt

RATIONALE: The maintenance of peripheral muscle mass may be compromised in chronic obstructive pulmonary disease (COPD) due to premature cellular senescence and exhaustion of the regenerative potential of the muscles. METHODS: Vastus lateralis biopsies were obtained from patients with COPD (n = 16) and healthy subjects (n = 7). Satellite cell number and the proportion of central nuclei, as a marker of muscle...

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PMID: 22720047
DOI: 10.1371/journal.pone.0039124

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