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Article

A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level.

PloS one - 1 Jan 2012

Tian Jin, Qi Wenbao, Li Xiaokang, He Jun, Jiao Peirong, Zhang Changhui, Liu Guo-Qian, Liao Ming

Abstract excerpt

While repeated infection of humans and enhanced replication and transmission in mice has attracted more attention to it, the pathogenesis of H9N2 virus was less known in mice. PB(2) residue 627 as the virulent determinant of H5N1 virus is associated with systemic infection and impaired TCR activation, but the impact of this position in H9N2 virus on the host immune response has not been evaluated. In this study,...

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Identifiers

PMID: 22719870
DOI: 10.1371/journal.pone.0038233
PMCID: PMC3374829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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