Article
DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma.
Annals of neurology - 1 Jun 2012
Blough Michael D, Al-Najjar Mohammad, Chesnelong Charles, Binding Carmen E, Rogers Alexandra D, Luchman H Artee, Kelly John J, Fliegel Larry, Morozova Olena, Yip Stephen, Marra Marco, Weiss Samuel, Chan Jennifer A, Cairncross J Gregory
Abstract excerpt
Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE-1 on 1p is silenced in oligodendrogliomas secondary to IDH-associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodendroglioma cells. Others have shown that rapid tumor growth cannot occur without NHE-1-mediated neutralization of the...
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