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Article

Generation of precursor cell lines from preneoplastic fields surrounding head and neck cancers.

Head & neck - 1 Apr 2013

van Zeeburg Hester J T, Graveland A Peggy, Brink Arjen, Nguyen Melanie, Leemans C René, Bloemena Elisabeth, Braakhuis Boudewijn J M, Brakenhoff Ruud H

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) develops in the mucosal linings of the upper aerodigestive tract. HNSCC may develop in large preneoplastic fields, which are in most cases invisible, but can be detected microscopically and by genetic analysis. METHODS: Cells of mucosal tissue biopsies were cultured and genetically analyzed. Genetic changes in established preneoplastic cultures were...

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Source

Identifiers

PMID: 22714984
DOI: 10.1002/hed.23004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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