Article
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women.
Menopause (New York, N.Y.) - 1 Nov 2012
Rah HyungChul, Jeon Young Joo, Choi Youngsok, Shim Sung Han, Yoon Tae Ki, Choi Dong Hee, Cha Sun Hee, Kim Nam Keun
Abstract excerpt
OBJECTIVE: The aim of our study was to investigate whether methylenetetrahydrofolate reductase (MTHFR) gene variant (MTHFR 677C>T) and thymidylate synthase (TS) gene variants (TS enhancer region [TSER] and TS 1494del6) confer a risk for premature ovarian failure (POF). METHODS: We genotyped 136 POF patients and 236 controls among Korean women for the three single nucleotide polymorphism sites using polymerase...
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