Article
Partial antiviral activities of the Asn631 chicken Mx against newcastle disease virus and vesicular stomatitis virus.
Molecular biology reports - 1 Aug 2012
Li Bichun, Fu Dezhi, Zhang Yani, Xu Qi, Ni Ligang, Chang Guobin, Zheng Mengmeng, Gao Bo, Sun Huaichang, Chen Guohong
Abstract excerpt
Conflicting data existed for the antiviral potential of the chicken Mx protein and the importance of the Asn631 polymorphism in determination of the antiviral activity. In this study we modified the chicken Mx cDNA from the Ser631 to Asn631 genotype and transfected them into COS-I cells, chicken embryonic fibroblast (CEF) or NIH 3T3 cells. The Mx protein was mainly located at the cytoplasm. The transfected cell...
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