Article
Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B.
Gastroenterology - 1 Sept 2012
Kennedy Patrick T F, Sandalova Elena, Jo Juandy, Gill Upkar, Ushiro-Lumb Ines, Tan Anthony T, Naik Sandhia, Foster Graham R, Bertoletti Antonio
Abstract excerpt
BACKGROUND & AIMS: Chronic hepatitis B (CHB) infection acquired perinatally or in early childhood has been associated with a prolonged phase of immune tolerance from viral exposure into early adulthood. The immune-tolerant phase of the disease is characterized by high levels of hepatitis B virus (HBV) DNA and normal liver biochemistry, with minimal or no fibrosis. We investigated whether the age of patients with...
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