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Article

Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutations.

Bioinformatics (Oxford, England) - 15 Aug 2012

Gray Vanessa E, Kukurba Kimberly R, Kumar Sudhir

Abstract excerpt

Site-directed mutagenesis is frequently used by scientists to investigate the functional impact of amino acid mutations in the laboratory. Over 10,000 such laboratory-induced mutations have been reported in the UniProt database along with the outcomes of functional assays. Here, we explore the pe...

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Identifiers

PMID: 22685075
DOI: 10.1093/bioinformatics/bts336
PMCID: PMC3413386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22685075-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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