Article
Gene mapping in Alport families with different basement membrane antigenic phenotypes.
Kidney international - 1 Nov 1990
Kashtan C E, Rich S S, Michael A F, de Martinville B
Abstract excerpt
The present study was undertaken to determine whether differences among Alport kindreds in the antigenic phenotypes of their basement membranes result from defects at distinct genetic loci or from allelic mutations at a single locus. We analyzed linkage of the Alport gene to polymorphic loci on the X chromosome in three families with Alport syndrome. In two of the families, epidermal basement membranes of...
Topics
- Antibodies
- Antigens
- Autoantibodies
- Basement Membrane
- Chromosome Mapping
- Collagen
- Female
- Genetic Linkage
- Humans
- Kidney Glomerulus
- Male
- Nephritis, Hereditary