Article
Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen.
American journal of human genetics - 1 Sept 1991
Morrison K E, Mariyama M, Yang-Feng T L, Reeders S T
Abstract excerpt
A novel type IV collagen, alpha 3(IV), has recently been identified in human and bovine basement membranes. Here we describe the cloning and sequencing of a cDNA encoding 218 residues of the NC1 domain of the human alpha 3(IV) chain. Of interest is the possible role of abnormalities of the alpha 3(IV) chain in Alport syndrome, as suggested by the failure to detect the NC1 domain of alpha 3(IV) in the basement...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Northern
- Chromosomes, Human, Pair 2
- Cloning, Molecular
- Collagen
- Humans
- Molecular Sequence Data
- Mutation
- Nephritis, Hereditary