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Article

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation.

PloS one - 1 Jan 2012

Bender Stephan, Rellum Thomas, Freitag Christine, Resch Franz, Rietschel Marcella, Treutlein Jens, Jennen-Steinmetz Christine, Brandeis Daniel, Banaschewski Tobias, Laucht Manfred

Abstract excerpt

BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O-methyltransferase genes (COMT) on the time-course of motor processing in a contingent negative variation (CNV) task. METHODS: 64-channel EEG recordings were obtained from...

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Identifiers

PMID: 22649558
DOI: 10.1371/journal.pone.0037814
PMCID: PMC3359334

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COMT

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