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Article

Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.

Psychoneuroendocrinology - 1 Jan 2013

Bourke Chase H, Raees Madiha Q, Malviya Sanjana, Bradburn Cory A, Binder Elisabeth B, Neigh Gretchen N

Abstract excerpt

Early life stress precipitates dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and this effect is most pronounced in females. The mechanisms that mediate female sensitivity to stress-induced HPA axis dysregulation are unknown. The purpose of this study was to determine whether sex moderates the effects of chronic adolescent stress on glucocorticoid receptor (GR) translocation and moderators of the...

Topics

Animals
Chronic Disease
Corticosterone
Cyclophilins
DNA-Binding Proteins
Dominance-Subordination
Female
Gene Expression Regulation, Developmental
Gonadal Steroid Hormones
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypothalamo-Hypophyseal System

Male

Phenotype

Pituitary-Adrenal System

Rats

Rats, Wistar

Receptors, Glucocorticoid

Restraint, Physical

Source

Open in PubMed Open full text

Identifiers

PMID: 22647578
DOI: 10.1016/j.psyneuen.2012.05.001
PMCID: PMC3443296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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