Article
Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population.
Medical oncology (Northwood, London, England) - 1 Dec 2012
Tomei Sara, Adams Sharon, Uccellini Lorenzo, Bedognetti Davide, De Giorgi Valeria, Erdenebileg Narnygerel, Ascierto Maria Libera, Reinboth Jennifer, Liu Qiuzhen, Bevilacqua Generoso, Wang Ena, Mazzanti Chiara, Marincola Francesco M
Abstract excerpt
HRAS belongs to the RAS genes superfamily. RAS genes are important players in several human tumors and the single-nucleotide polymorphism rs12628 has been shown to contribute to the risk of bladder, colon, gastrointestinal, oral, and thyroid carcinoma. We hypothesized that this SNP may affect the risk of cutaneous melanoma as well. HRAS gene contains a polymorphic region (rs112587690), a repeated hexanucleotide...
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