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Article

Aspartoacylase supports oxidative energy metabolism during myelination.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Sept 2012

Francis Jeremy S, Strande Louise, Markov Vladamir, Leone Paola

Abstract excerpt

The inherited leukodystrophy Canavan disease arises due to a loss of the ability to catabolize N-acetylaspartic acid (NAA) in the brain and constitutes a major point of focus for efforts to define NAA function. Accumulation of noncatabolized NAA is diagnostic for Canavan disease, but contrasts with the abnormally low NAA associated with compromised neuronal integrity in a broad spectrum of other clinical...

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Identifiers

PMID: 22617649
DOI: 10.1038/jcbfm.2012.66
PMCID: PMC3434629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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