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Article

Evolutionary constraint helps unmask a splicing regulatory region in BRCA1 exon 11.

PloS one - 1 Jan 2012

Raponi Michela, Douglas Andrew G L, Tammaro Claudia, Wilson David I, Baralle Diana

Abstract excerpt

BACKGROUND: Alternative splicing across exon 11 produces several BRCA1 isoforms. Their proportion varies during the cell cycle, between tissues and in cancer suggesting functional importance of BRCA1 splicing regulation around this exon. Although the regulatory elements driving exon 11 splicing have never been identified, a selective constraint against synonymous substitutions (silent nucleotide variations that...

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Identifiers

PMID: 22615956
DOI: 10.1371/journal.pone.0037255
PMCID: PMC3353946

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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