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Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset

18 May 2012

Abstract excerpt

Coagulation disorders often accompany cancer onset and evolution, which, if not properly managed, could have grave consequences. Endothelial protein C is an important regulator of homeostasis and acts through its high affinity binding to its transmembrane receptor (EPCR). Soluble (sEPCR) which results from the proteolytic cleavage of the membrane bound form can trap activated endothelial protein C and deprive it...

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PMID: 22614534
DOI: 10.3892/ijo.2012.1492

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