Article
SMARCB1 deficiency in tumors from the peripheral nervous system: a link between schwannomas and rhabdoid tumors?
The American journal of surgical pathology - 1 Jul 2012
Rizzo Daniela, Fréneaux Paul, Brisse Hervé, Louvrier Camille, Lequin Delphine, Nicolas André, Ranchère Dominique, Verkarre Virginie, Jouvet Anne, Dufour Christelle, Edan Christine, Stéphan Jean-Louis, Orbach Daniel, Sarnacki Sabine, Pierron Gaëlle, Parfait Béatrice, Peuchmaur Michel, Delattre Olivier, Bourdeaut Franck
Abstract excerpt
BACKGROUND: Inactivation of SMARCB1 tumor-suppressor gene was originally described as highly specific for rhabdoid tumors (RTs). Nevertheless, recent reports have illustrated that SMARCB1 alterations also characterize other tumors; in particular, some familial schwannomatosis and epithelioid malignant peripheral nerve sheath tumors, both from peripheral nervous system (PNS) origin, lack BAF47 expression. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.