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Article

Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.

Gynecologic oncology - 1 Sept 2012

Nout Remi A, Bosse Tjalling, Creutzberg Carien L, Jürgenliemk-Schulz Ina M, Jobsen Jan J, Lutgens Ludy C H W, van der Steen-Banasik Elzbieta M, van Eijk Ronald, Ter Haar Natalja T, Smit Vincent T H B M

Abstract excerpt

OBJECTIVE: To investigate if analysis of genetic alterations in the main pathways involved in endometrioid type carcinogenesis (PI3K-AKT, Wnt/β-catenin, P53-activation and MSI) improves the current risk assessment based on clinicopathological factors. METHODS: Formalin fixed paraffin embedded (FFPE) primary tumor samples of 65 patients with FIGO-stage I endometrioid type endometrial cancer (EEC) were selected...

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Source

Identifiers

PMID: 22609107
DOI: 10.1016/j.ygyno.2012.05.012

Genes

KRAS
MLH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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