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Article

Thermophilic glycosynthases for oligosaccharides synthesis.

Methods in enzymology - 1 Jan 2012

Cobucci-Ponzano Beatrice, Perugino Giuseppe, Strazzulli Andrea, Rossi Mosè, Moracci Marco

Abstract excerpt

Glycosynthases are engineered glycoside hydrolases that in suitable reaction conditions promote the synthesis of oligosaccharides with exquisite stereoselectivity and enhanced regioselectivity, if compared to traditional chemical methods. This approach was demonstrated to be successful in a number of cases including β-glycosynthases acting at the termini or within an oligosaccharide chain (exo- and...

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PMID: 22608732
DOI: 10.1016/B978-0-12-415931-0.00015-X

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