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High-Throughput Sequencing Detects Minimal Residual Disease in Acute T Lymphoblastic Leukemia

16 May 2012

Abstract excerpt

High-throughput sequencing (HTS) of lymphoid receptor genes is an emerging technology that can comprehensively assess the diversity of the immune system. Here, we applied HTS to the diagnosis of T-lineage acute lymphoblastic leukemia/lymphoma. Using 43 paired patient samples, we then assessed minimal residual disease (MRD) at day 29 after treatment. The variable regions of TCRB and TCRG were sequenced using an...

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PMID: 22593176
DOI: 10.1126/scitranslmed.3003656

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