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Article

PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 May 2012

Edwards Mark R, Johnson James R, Rankin Kimberley, Jenkins Rosalind E, Maguire Carl, Morgan Alan, Burgoyne Robert D, Barclay Jeff W

Abstract excerpt

Diacylglycerol (DAG)/protein kinase C (PKC) signaling plays an integral role in the regulation of neuronal function. This is certainly true in Caenorhabditis elegans and in particular for thermosensory signaling and behavior. Downstream molecular targets for transduction of this signaling cascade remain, however, virtually uncharacterized. We investigated whether PKC phosphorylation of Munc18-1, an essential...

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Identifiers

PMID: 22593072
DOI: 10.1523/JNEUROSCI.4029-11.2012
PMCID: PMC3374327

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