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Article

Analysis of KLLN as a high-penetrance breast cancer predisposition gene.

Breast cancer research and treatment - 1 Jul 2012

Thompson Ella R, Gorringe Kylie L, Choong David Y H, Eccles Diana M, Mitchell Gillian, Campbell Ian G

Abstract excerpt

KLLN is a p53 target gene with DNA binding function and represents a highly plausible candidate breast cancer predisposition gene. We screened for predisposing variants in 860 high-risk breast cancer families using high resolution melt analysis. A germline c.339_340delAG variant predicted to caus...

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Source

Identifiers

PMID: 22580995
DOI: 10.1007/s10549-012-2088-3

Genes

KLLN
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22580995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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