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Article

Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila.

Biochimica et biophysica acta - 1 Aug 2012

Alves Ema, Henriques Bárbara J, Rodrigues João V, Prudêncio Pedro, Rocha Hugo, Vilarinho Laura, Martinho Rui G, Gomes Cláudio M

Abstract excerpt

Following a screening on EMS-induced Drosophila mutants defective for formation and morphogenesis of epithelial cells, we have identified three lethal mutants defective for the production of embryonic cuticle. The mutants are allelic to the CG12140 gene, the fly homologue of electron transfer flavoprotein:ubiquinone oxidoreductase (ETF:QO). In humans, inherited defects in this inner membrane protein account for...

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PMID: 22580358
DOI: 10.1016/j.bbadis.2012.05.003

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MADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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