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Article

Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in Malaysian subjects.

Journal of biomedicine & biotechnology - 1 Jan 2012

Al-Hamodi Zaid, Saif-Ali Riyadh, Ismail Ikram S, Ahmed Khaled A, Muniandy Sekaran

Abstract excerpt

Elevated activity of plasminogen activator inhibitor-1 (PAI-1) and decreased tissue plasminogen activator (tPA) activity are considered to be important risk factors for type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). The aim of this study was to investigate the association of the PAI-1 4G/5G and tPA Alu-repeat I/D polymorphisms with T2DM in Malaysian subjects. Serum insulin, coronary risk panel,...

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Source

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Identifiers

PMID: 22577291
DOI: 10.1155/2012/234937
PMCID: PMC3336151

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Source receipt: pubmed, retrieved 7 Sept 2026.

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