Article
A human laterality disorder associated with recessive CCDC11 mutation.
Journal of medical genetics - 1 Jun 2012
Perles Zeev, Cinnamon Yuval, Ta-Shma Asaf, Shaag Avraham, Einbinder Tom, Rein Azaria J J T, Elpeleg Orly
Abstract excerpt
BACKGROUND: Significant advancements in understanding the molecular pathophysiology of laterality determination were recently made. However, there are large gaps in our knowledge of the initial processes that lead to laterality defects, such as heterotaxy syndrome (HS, also known as situs ambiguous) and situs inversus totalis (SIT). The former refers to abnormal distribution of visceral organs, and the latter...
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