Article
CUBN as a novel locus for end-stage renal disease: insights from renal transplantation.
PloS one - 1 Jan 2012
Reznichenko Anna, Snieder Harold, van den Born Jacob, de Borst Martin H, Damman Jeffrey, van Dijk Marcory C R F, van Goor Harry, Hepkema Bouke G, Hillebrands Jan-Luuk, Leuvenink Henri G D, Niesing Jan, Bakker Stephan J L, Seelen Marc, Navis Gerjan
Abstract excerpt
Chronic kidney disease (CKD) is a complex disorder. As genome-wide association studies identified cubilin gene CUBN as a locus for albuminuria, and urinary protein loss is a risk factor for progressive CKD, we tested the hypothesis that common genetic variants in CUBN are associated with end-stage renal disease (ESRD) and proteinuria. First, a total of 1142 patients with ESRD, admitted for renal transplantation,...
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