Article
Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers.
PloS one - 1 Jan 2012
Yiu Kai Hang, Atsma Douwe E, Delgado Victoria, Ng Arnold C T, Witkowski Tomasz G, Ewe See Hooi, Auger Dominique, Holman Eduard R, van Mil Anneke M, Breuning Martijn H, Tse Hung Fat, Bax Jeroen J, Schalij Martin J, Marsan Nina Ajmone
Abstract excerpt
BACKGROUND: To evaluate the presence of myocardial structural alterations and subtle myocardial dysfunction during familial screening in asymptomatic mutation carriers without hypertrophic cardiomyopathy (HCM) phenotype. METHODS AND FINDINGS: Sixteen HCM families with pathogenic mutation were studied and 46 patients with phenotype expression (Mut+/Phen+) and 47 patients without phenotype expression (Mut+/Phen-)...
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