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Article

The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation.

PloS one - 1 Jan 2012

Li Yu-Yin, Bao Yong-Li, Song Zhen-Bo, Sun Lu-Guo, Wu Ping, Zhang Yu, Fan Cong, Huang Yan-Xin, Wu Yin, Yu Chun-Lei, Sun Ying, Zheng Li-Hua, Wang Guan-Nan, Li Yu-Xin

Abstract excerpt

BACKGROUND: Testes-specific protease 50 (TSP50), a newly discovered threonine enzyme, has similar amino acid sequences and enzymatic structures to those of many serine proteases. It may be an oncogene. TSP50 is up-regulated in breast cancer epithelial cells, and ectopic expression of TSP50 in TSP50-deficient Chinese hamster ovary (CHO) cells has been found to promote cell proliferation. However, the mechanisms by...

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PMID: 22574111
DOI: 10.1371/journal.pone.0035030
PMCID: PMC3344824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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