The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer.

doi:10.1002/ijc.27628

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Article

The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer.

International journal of cancer - 15 Sept 2012

Kloth Michael, Goering Wolfgang, Ribarska Teodora, Arsov Christian, Sorensen Karina Dalsgaard, Schulz Wolfgang A

Abstract excerpt

Epigenetic aberrations are frequent in prostate cancer and could be useful for detection and prognostication. However, the underlying mechanisms and the sequence of these changes remain to be fully elucidated. The tumor suppressor gene RARRES1 (TIG1) is frequently hypermethylated in several cancers. Having noted changes in the expression of its paralogous neighbor gene LXN at 3q25.32, we used pyrosequencing to...

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Share to Antigens
Share to Cell Line, Tumor
Share to DNA Methylation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

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Share to Transcription, Genetic

Source

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Identifiers

PMID: 22573467
DOI: 10.1002/ijc.27628

Genes

RARRES1
LXN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.