Article
Protective activity of Streptococcus pneumoniae Spr1875 protein fragments identified using a phage displayed genomic library.
PloS one - 1 Jan 2012
Cardaci Angela, Papasergi Salvatore, Midiri Angelina, Mancuso Giuseppe, Domina Maria, Cariccio Veronica Lanza, Mandanici Francesca, Galbo Roberta, Lo Passo Carla, Pernice Ida, Donato Paolo, Ricci Susanna, Biondo Carmelo, Teti Giuseppe, Felici Franco, Beninati Concetta
Abstract excerpt
There is considerable interest in pneumococcal protein antigens capable of inducing serotype-independent immunoprotection and of improving, thereby, existing vaccines. We report here on the immunogenic properties of a novel surface antigen encoded by ORF spr1875 in the R6 strain genome. An antigenic fragment encoded by spr1875, designated R4, was identified using a Streptococcus pneumoniae phage displayed genomic...
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