Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel.

Cancer chemotherapy and pharmacology - 1 Jun 2012

Uchiyama Toshitaka, Kanno Hitoshi, Ishitani Ken, Fujii Hisaichi, Ohta Hiroaki, Matsui Hideo, Kamatani Naoyuki, Saito Kayoko

Abstract excerpt

PURPOSE: Docetaxel is one of the most widely used chemotherapy drugs for gynecological cancers. A dose-limiting factor of docetaxel is severe neutropenia, and previous reports showed that grade 4 neutropenia was observed in approximately 70% of Japanese patients treated with docetaxel. In order t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Antineoplastic Agents
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Docetaxel

Share to Genital Neoplasms, Female

Share to Neutropenia

Share to Steroid Hydroxylases

Share to Taxoids

Source

Identifiers

PMID: 22562553
DOI: 10.1007/s00280-012-1872-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22562553-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel.PMID 22562553Read ↗

Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics.Semantic proximity Read ↗

ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy.Semantic proximity Read ↗

Genetic associations of docetaxel-based chemotherapy-induced myelosuppression in Chinese Han population.Semantic proximity Read ↗

CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.Semantic proximity Read ↗

Predicting paclitaxel-induced neutropenia using the DMET platform.Semantic proximity Read ↗

Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries.Semantic proximity Read ↗

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.Semantic proximity Read ↗

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohortSemantic proximity Read ↗

NEF2L2 rs35652124C>T Polymorphism Predicts Grade 4 Neutropenia in Esophageal Cancer Patients Treated with Docetaxel, Cisplatin, and Fluorouracil Chemotherapy: Results from Exploratory and Validation CohortsSemantic proximity Read ↗

The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).Semantic proximity Read ↗

ABCG2 genetic variant as risk factor for neutropenia in patients with metastatic or advanced hormone receptor -positive, HER2-negative breast cancer treated with palbociclibSemantic proximity Read ↗

Association between gene polymorphism and adverse effects in cancer patients receiving docetaxel treatment: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.