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Article

Computational studies of the metal-binding site of the wild-type and the H46R mutant of the copper, zinc superoxide dismutase.

Inorganic chemistry - 21 May 2012

Mera-Adasme Raúl, Mendizábal Fernando, Gonzalez Mauricio, Miranda-Rojas Sebastián, Olea-Azar Claudio, Sundholm Dage

Abstract excerpt

Impairment of the Zn(II)-binding site of the copper, zinc superoxide dismutase (CuZnSOD) protein is involved in a number of hypotheses and explanations for the still unknown toxic gain of function mutant varieties of CuZnSOD that are associated with familial forms of amyotrophic lateral sclerosis (ALS). In this work, computational chemistry methods have been used for studying models of the metal-binding site of...

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PMID: 22545761
DOI: 10.1021/ic202416d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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