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Article

Asymmetric Bidirectional Transcription from the FSHD-Causing D4Z4 Array Modulates DUX4 Production

20 Apr 2012

Abstract excerpt

Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4). The expression of DUX4 depends on an open chromatin conformation of the D4Z4 macrosatellite array and a specific haplotype on chromosome 4. Even when these requirements are met, DUX4 transcripts and protein are only detectable in a...

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PMID: 22536400
DOI: 10.1371/journal.pone.0035532

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Asymmetric Bidirectional Transcription from the FSHD-Causing D4Z4 Array Modulates DUX4 ProductionPMID 22536400Read ↗

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