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Article

Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases.

Molecules (Basel, Switzerland) - 9 Dec 2022

Wang Sifan, Kang Yuanbo, Wang Ruifeng, Deng Junqi, Yu Yupei, Yu Jun, Wang Junpu

Abstract excerpt

NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) is an essential core subunit and component of the iron-sulfur (FeS) fragment of mitochondrial complex I directly involved in the electron transfer process and energy metabolism. Pathogenic variants of the NDUFS8 are relevant to infantile-onset and severe diseases, including Leigh syndrome, cancer, and diabetes mellitus. With over 1000 nuclear genes...

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PMID: 36557887
DOI: 10.3390/molecules27248754
PMCID: PMC9783039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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