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Article

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction.

Psychiatry research - 30 Aug 2012

Bishop Jeffrey R, Chae Sharon S, Patel Shitalben, Moline Jessica, Ellingrod Vicki L

Abstract excerpt

We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22534499
DOI: 10.1016/j.psychres.2012.03.048
PMCID: PMC3458139

Genes

GRIA1
GRIA3
GRIK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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