Inheritance patterns of noise vulnerability and "protectability" in (C57BL/6J × CBA/J) F1 hybrid mice.

doi:10.3766/jaaa.23.5.4

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Article

Inheritance patterns of noise vulnerability and "protectability" in (C57BL/6J × CBA/J) F1 hybrid mice.

Journal of the American Academy of Audiology - 1 May 2012

Barden Emily K, Rellinger Erin A, Ortmann Amanda J, Ohlemiller Kevin K

Abstract excerpt

BACKGROUND: Interindividual variation in cochlear vulnerability to noise and ototoxins must in part reflect allelic variation in genes that largely remain unknown. Work in our laboratory has shown that young adult CBA/J mice are more vulnerable to cochlear noise injury than are similar-aged mice of other well-studied strains such as C57BL/6J (B6). Conversely, young CBA/J mice are dramatically protected against...

Topics

Alleles
Animals
Anti-Bacterial Agents
Auditory Fatigue
Evoked Potentials, Auditory, Brain Stem
Female
Hearing Loss, Noise-Induced
Hybridization, Genetic
Injections, Subcutaneous
Kanamycin
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Noise
Sound Spectrography

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Open in PubMed

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PMID: 22533976
DOI: 10.3766/jaaa.23.5.4

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