Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

Article

Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

Cancer research - 15 Dec 1990

Fornace A J, Papathanasiou M A, Hollander M C, Yarosh D B

Abstract excerpt

DNA probes prepared from human O6-methylguanine-DNA methyltransferase complementary DNA were hybridized to mRNA isolated from human liver and fifteen human tumor cell lines proficient (Mer+) or deficient (Mer-) in transferase activity. Liver and Mer+ cells contained levels of transferase-specific...

Topics

Cell Line
Gene Expression
Humans
Methyl Methanesulfonate
Methylnitronitrosoguanidine
Methyltransferases
Neoplasms
O(6)-Methylguanine-DNA Methyltransferase
Phenotype
RNA, Messenger
X-Rays

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